Medications development for the treatment of alcohol use disorder: insights into the predictive value of animal and human laboratory models.

ABSTRACT: Development of effective treatments for alcohol use disorder (AUD) represents an important public health goal. This review provides a summary of completed preclinical and clinical studies testing pharmacotherapies for the treatment of AUD. We discuss opportunities for improving the translation from preclinical findings to clinical trial outcomes, focusing on the validity and predictive value of animal and human laboratory models of AUD. Specifically, while preclinical studies of medications development have offered important insights into the neurobiology of the disorder and alcohol's molecular targets, limitations include the lack of standardized methods and streamlined processes whereby animal studies can readily inform human studies. Behavioral pharmacology studies provide a less expens

SUBMITTER: Yardley MM 

PROVIDER: S-EPMC4969222 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature