Disrupted functional connectivity in adolescent obesity.

ABSTRACT:

Background/objective

Obesity has been associated with brain alterations characterised by poorer interaction between a hypersensitive reward system and a comparatively weaker prefrontal-cognitive control system. These alterations may occur as early as in adolescence, but this notion remains unclear, as no studies so far have examined global functional connectivity in adolescents with excess weight.

Subjects/methods

We investigated functional connectivity in a sample of 60 adolescents with excess weight and 55 normal weight controls. We first identified parts of the brain displaying between-group global connectivity differences and then characterised the extent of the differences in functional network integrity and their association with reward sensitivity.

Results

Adol

SUBMITTER: Moreno-Lopez L 

PROVIDER: S-EPMC4969269 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature