Extravascular modified lipoproteins: a role in the propagation of diabetic retinopathy in a mouse model of type 1 diabetes.

ABSTRACT:

Aims/hypothesis

We aimed to determine whether plasma lipoproteins, after leakage into the retina and modification by glycation and oxidation, contribute to the development of diabetic retinopathy in a mouse model of type 1 diabetes.

Methods

To simulate permeation of plasma lipoproteins into retinal tissues, streptozotocin-induced mouse models of diabetes and non-diabetic mice were challenged with intravitreal injection of human 'highly-oxidised glycated' low-density lipoprotein (HOG-LDL), native- (N-) LDL, or the vehicle PBS. Retinal histology, electroretinography (ERG) and biochemical markers were assessed over the subsequent 14 days.

Results

Intravitreal administration of N-LDL and PBS had no effect on retinal structure or function in either diabetic or non-diabetic

SUBMITTER: Yu JY 

PROVIDER: S-EPMC4969344 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature