Cutaneous Sporotrichosis Presenting as Clinical Feature of Facial Cellulitis in an Adult.
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ABSTRACT:
SUBMITTER: Song JG
PROVIDER: S-EPMC4969487 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Cutaneous Sporotrichosis Presenting as Clinical Feature of Facial Cellulitis in an Adult.
Song Jun Gyu JG Song You Bum YB Yun Sang Youl SY Suh Moo Kyu MK Ha Gyoung Yim GY Kim Jung Ran JR Choi Jong Soo JS
Annals of dermatology 20160726 4
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Project description: Not available
| S-EPMC5597664 | biostudies-literature
Project description:This is a case report of feline sporotrichosis in a 3-year-old male intact DSH stray cat in Bangkok, Thailand. Cytology and histopathology revealed Sporothrix yeast-like organisms in ulcerative cutaneous lesions. Fungal culture and sequence analysis of ITS region of rDNA confirmed the diagnosis and the causative agent as Sporothrix schenckii. This is the first case report of feline sporotrichosis in the country. The case report emphasizes the role of stray cats as this zoonotic disease carrier.
| S-EPMC6312868 | biostudies-literature
Project description:A 6-year-old boy was referred to our hospital with orbital cellulitis. He had a history of 7 days of fever despite antibiotherapy. At first, he only had pharyngitis and conjunctivitis, but then an orbital mass evolved which restricted the movement of his right eye and there was also periorbital inflammation resembling orbital cellulitis. Examination at presentation revealed conjunctivitis with secretion, periocular inflammation and edema, right-preauricular lymphadenopathy and restriction of upgaze in the right eye. Laboratory findings included a white blood cell count of 19,000 cells per mm3, with 81.5% neutrophils, 15.0% lymphocytes, 1.2% monocytes and 0.4% basophils. The erythrocyte sedimentation rate was 52 mm/h and the C-reactive protein level was 46.3 mg/dl. Magnetic resonance imaging confirmed orbital cellulitis and pansinusitis. Vancomycin (60 mg/kg/day) and meropenem (100 mg/kg/day) were administered, but desquamation on his fingertips and a rash appeared on the tenth day. A pediatric consultation resulted in a diagnosis of incomplete Kawasaki disease (KD). After administration of aspirin, the orbital inflammation regressed in 3 days. No coronary artery lesions were detected on the first echocardiography, but these did appear 6 weeks later. This confirmed the KD diagnosis.
| S-EPMC3901586 | biostudies-literature
Project description:Sporotrichosis is a global occurring implantation (subcutaneous) mycosis, caused by Sporothrix species, usually affecting the skin and the lymphatic vessels, from where it can disseminate. Nowadays, the vast majority of sporotrichosis infections in Brazil are caused by zoonotic transmission of S. brasiliensis which is the main etiologic agent. We report a cutaneous disseminated case of this disease, observed in an immunocompetent farmer living in southern Brazil, the Sporothrix schenckii-infection was successfully treated with itraconazole.
| S-EPMC9109117 | biostudies-literature
Project description:BackgroundPregnant women with sporotrichosis should not receive systemic antifungal therapy except in severe cases when amphotericin B is recommended. Thermotherapy is the most reported treatment described in this group of patients. It entails weeks of daily self-application of heat to the lesions, requires that the patient faithfully apply it, and it could cause skin burns. Cryosurgery is a useful therapeutic tool for many cutaneous infectious diseases, safe for pregnant women, but not well evaluated for sporotrichosis treatment in this group.MethodologyThe authors conducted a retrospective study describing epidemiological, clinical, and therapeutic data related to four pregnant patients with sporotrichosis treated with cryosurgery. The authors reviewed the clinical records of four pregnant patients diagnosed with cutaneous sporotrichosis and treated with cryosurgery. The sessions were carried out monthly up to clinical cure. Molecular identification of the Sporothrix species was performed in two cases using T3B PCR fingerprinting assays.Principal findingsAll patients were in the second trimester of pregnancy and their age ranged from 18 to 34 years. With regard to clinical presentation, two patients had lymphocutaneous and two had the fixed form. S. brasiliensis was identified in two cases as the causative agent. Cryosurgery was well tolerated and the number of sessions ranged from 1 to 3. All the patients reached a complete clinical cure.ConclusionsCryosurgery was a safe, easy to perform and well tolerated method, and therefore it is suggested to be a suitable option for the treatment of cutaneous sporotrichosis in pregnant women.
| S-EPMC5933803 | biostudies-literature
Project description:BackgroundAn outbreak of cutaneous sporotrichosis occurred in the Darwin region of the Northern Territory (NT) in 2014. We aimed to determine the source and risk factors associated with the outbreak and describe the clinical spectrum of cases seen.MethodsEpidemiological investigation of cases of cutaneous sporotrichosis identified through the Royal Darwin Hospital was undertaken to investigate risk factors and potential sources of infection. Data were collected through chart review and individual patient interviews. Environmental investigation followed identification of a common risk factor.ResultsNine confirmed cases of cutaneous sporotrichosis caused by Sporothrix schenckii were identified with onset of symptoms between April and July 2014. Patients were aged 29 to 70 years and seven were male (78%). Two strains of S. schenckii were identified, neither of which have been previously documented. One common risk factor was identified: all patients were occupational or recreational gardeners, with each reporting exposure to mulching hay, originating from a single NT farm. Local environmental health officers visited the farm and the owners confirmed that the implicated hay had been stored over the monsoon season and had been affected by rain. Storage of hay over the wet season was a new practice.ConclusionsThis constitutes the third reported outbreak of S. schenckii sporotrichosis attributable to contaminated hay in Australia and the first outbreak of sporotrichosis in the NT. This outbreak prompted public health interventions, including distribution of information to general practitioners, farmers and suppliers in the Top End. Media reporting led to the identification and treatment of an additional case. Local practitioners should remain alert to the possibility of further occurrences of sporotrichosis.
| S-EPMC4711041 | biostudies-literature
Project description:Implementation of a guideline for the management of hospitalized adults with uncomplicated skin and soft-tissue infections may decrease unnecessary antibiotic use. For cellulitis, treatment with vancomycin and broad-spectrum antibiotics decreased significantly. For cutaneous abscess, treatment with broad-spectrum antibiotics decreased significantly. There were no differences in rates of treatment failure, recurrence, or adverse events.
| S-EPMC5781223 | biostudies-literature
Project description:BackgroundCutaneous sporotrichosis is prevalent worldwide and a common subcutaneous fungal disease in northeast China. The incidence of cutaneous sporotrichosis in southern China cannot be ignored. Previous studies have revealed differences between different regions in China regarding populations susceptible to infection, cause of infection, and pathological mechanisms of sporotrichosis. Therefore, This study aimed to analyze the differences in the epidemiological characteristics of cutaneous sporotrichosis in different regions of China to provide a reference for regional prevention, control, and treatment.MethodsWe searched PubMed, EMBASE, Cochrane Library, CNKI, WanFang Data, and VIP for published reports on cutaneous sporotrichosis in China. The information about the characteristics of populations getting cutaneous sporotrichosis, causes of infection, disease types, and treatment regimens was extracted from studies to construct a knowledge database of cutaneous sporotrichosis in China. Taking the Qinling Mountains-Huaihe River line as the boundary to divide China into the northern and southern, the epidemiological characteristics of cutaneous sporotrichosis in two parts of China were analyzed.ResultsIn northern China, more women than men get cutaneous sporotrichosis (60.4% vs. 39.6%), while it is the other way around in southern China (men vs. women: 50.6% vs. 49.4%). In northern China, the incidence of this disease was more concentrated in spring (34.0%) and winter (35.7%), while in southern China, this disease frequently spread in spring (48.1%) and summer (26.9%). In the north, cutaneous sporotrichosis usually affected the face (50.1%) and limbs (45.3%), while in the south, it targets limbs (72.6%). In northern China, potassium iodide (30.5%) and combination therapy (37.8%) were preferred, while in southern China, potassium iodide (86.0%) was the main choice. Although there was a significant difference in treatment regimens (P<0.05), no significant difference emerged in cure rates between northern and southern China (98.5% vs. 98.4%, P>0.05).ConclusionsIt is the first retrospective study on sporotrichosis in China. It describes the prevention of sporotrichosis in China since it was first reported and also reflects the differences in sporotrichosis between the northern and southern of China. This study provides a valuable reference for the prevention, control, and treatment of sporotrichosis in different regions of China.
| S-EPMC10009553 | biostudies-literature
Project description:We report a 26-year-old Thai man who presented with hypoparathyroidism in adulthood. He had no history of cardiac disease and recurrent infection. His subtle dysmorphic facial features and mild intellectual impairment were suspected for chromosome 22q11.2 deletion syndrome. The diagnosis was confirmed by fluorescence in situ hybridization, which found microdeletion in 22q11.2 region. The characteristic facial appearance can lead to clinical suspicion of this syndrome. The case report emphasizes that this syndrome is not uncommon and presents as a remarkable variability in the severity and extent of expression. Accurate diagnosis is important for genetic counseling and long-term health supervision by multidisciplinary team.
| S-EPMC3657414 | biostudies-literature
Project description:BackgroundCutaneous disseminated sporotrichosis (CDS), also called hematogenous sporotrichosis, is a rare condition that usually affects immunocompromised patients. The current work presents the case of a woman with diabetes mellitus associated with CDS.Case presentationA 59-year-old woman with diabetes mellitus presented with a two-year history of ulcerated rashes on the left ankle and both sides of the jaw. Physical examination revealed three annular areas of erythematous and raised plaque with an ulcer over the left ankle and both sides of the jaw. Based on laboratory findings, elevated blood glucose concentration and decreased white cell count were observed. Sporothrix globosa was identified in the mycological culture of biopsied tissue from the three lesions and this was confirmed by DNA sequencing. The skin lesions healed after two-month itraconazole therapy.ConclusionsDiabetes is a risk factor for disseminated sporotrichosis, which may be induced by hematogeneous spread, repeated inoculation, or autoinoculation. This study raises awareness among clinicians, with regard to the notion that people with possibly altered immune function are potentially vulnerable to severe clinical forms of sporotrichosis.
| S-EPMC10538719 | biostudies-literature