CREB-BDNF pathway influences alcohol cue-elicited activation in drinkers.

ABSTRACT: Alcohol use disorder (AUD) is suggested to have polygenic risk factors and also exhibits neurological complications, strongly encouraging a translational study to explore the associations between aggregates of genetic variants and brain function alterations related to alcohol use. In this study, we used a semiblind multivariate approach, parallel independent component analysis with multiple references (pICA-MR) to investigate relationships of genome-wide single nucleotide polymorphisms with alcohol cue-elicited brain activations in 315 heavy drinkers, where pICA-MR assesses multiple reference genes for their architecture and functional influences on neurobiological conditions. The genetic component derived from the cAMP-response element-binding protein and -brain derived neurotrophic facto

SUBMITTER: Chen J 

PROVIDER: S-EPMC4969622 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature