Lack of concordance between residual viremia and viral variants driving de novo infection of CD4(+) T cells on ART.

ABSTRACT:

Background

In most patients, current antiretroviral therapy (ART) regimens can rapidly reduce plasma viral load. However, even after years of effective treatment, a significant proportion of patients show residual plasma viremia below the clinical detection limit. Although residual viremia might be associated with increased chronic immune activation and morbidity, its origin and its potential role in the replenishment of the viral reservoir during suppressive ART is not completely understood. We performed an in-depth genetic analysis of the total and episomal cell-associated viral DNA (vDNA) repertoire in purified CD4(+) T cell subsets of three HIV-infected individuals, and used phylogenetic analysis to explore its relationship with plasma viruses.

Results

The predominant pr

SUBMITTER: Puertas MC 

PROVIDER: S-EPMC4970251 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature