Genetic analysis of variation in lifespan using a multiparental advanced intercross Drosophila mapping population.

ABSTRACT:

Background

Considerable natural variation for lifespan exists within human and animal populations. Genetically dissecting this variation can elucidate the pathways and genes involved in aging, and help uncover the genetic mechanisms underlying risk for age-related diseases. Studying aging in model systems is attractive due to their relatively short lifespan, and the ability to carry out programmed crosses under environmentally-controlled conditions. Here we investigate the genetic architecture of lifespan using the Drosophila Synthetic Population Resource (DSPR), a multiparental advanced intercross mapping population.

Results

We measured lifespan in females from 805 DSPR lines, mapping five QTL (Quantitative Trait Loci) that each contribute 4-5 % to among-line lifespan varia

SUBMITTER: Highfill CA 

PROVIDER: S-EPMC4970266 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature