Protein arginine methyltransferase 5 regulates multiple signaling pathways to promote lung cancer cell proliferation.

ABSTRACT:

Background

Protein arginine methyltransferase 5 (PRMT5) catalyzes the formation of symmetrical dimethylation of arginine residues in proteins. WD repeat domain 77 (WDR77), also known as p44, MEP50, or WD45, forms a stoichiometric complex with PRMT5. The PRMT5/p44 complex is required for cellular proliferation of lung and prostate epithelial cells during earlier stages of development and is re-activated during prostate and lung tumorigenesis. The molecular mechanisms by which PRMT5 and p44 promote cellular proliferation are unknown.

Methods

Expression of PRMT5 and p44 in lung and prostate cancer cells was silenced and their target genes were identified. The regulation of target genes was validated in various cancer cells during lung development and tumorigenesis. Altered expr

SUBMITTER: Sheng X 

PROVIDER: S-EPMC4970276 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature