Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review.

ABSTRACT:

Aim

To investigate roles of genetic polymorphisms in non-alcoholic fatty liver disease (NAFLD) onset, severity, and outcome through systematic literature review.

Methods

The authors conducted both systematic and specific searches of PubMed through December 2015 with special emphasis on more recent data (from 2012 onward) while still drawing from more historical data for background. We identified several specific genetic polymorphisms that have been most researched and, at this time, appear to have the greatest clinical significance on NAFLD and similar hepatic diseases. These were further investigated to assess their specific effects on disease onset and progression and the mechanisms by which these effects occur.

Results

We focus particularly on genetic polymorphisms

SUBMITTER: Severson TJ 

PROVIDER: S-EPMC4970479 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature