The diagnostic discrimination of cutaneous α-synuclein deposition in Parkinson disease.

ABSTRACT:

Objective

To determine the diagnostic discrimination of cutaneous α-synuclein deposition in individuals with Parkinson disease (PD) with and without autonomic dysfunction on autonomic testing, in early and late stages of the disease, and of short and long duration.

Methods

Twenty-eight participants with PD and 23 control participants were studied by skin biopsies at multiple sites, autonomic function testing, and disease-specific scales.

Results

Skin biopsies provide >90% sensitivity and >90% specificity to distinguish PD from control participants across all biopsies sites with quantification of either pilomotor or sudomotor α-synuclein deposition. All individuals with PD have significantly higher cutaneous α-synuclein deposition than control participants, even those

SUBMITTER: Gibbons CH 

PROVIDER: S-EPMC4970658 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature