Polygenic risk of Alzheimer disease is associated with early- and late-life processes.

ABSTRACT:

Objective

To examine associations between aggregate genetic risk and Alzheimer disease (AD) markers in stages preceding the clinical symptoms of dementia using data from 2 large observational cohort studies.

Methods

We computed polygenic risk scores (PGRS) using summary statistics from the International Genomics of Alzheimer's Project genome-wide association study of AD. Associations between PGRS and AD markers (cognitive decline, clinical progression, hippocampus volume, and β-amyloid) were assessed within older participants with dementia. Associations between PGRS and hippocampus volume were additionally examined within healthy younger participants (age 18-35 years).

Results

Within participants without dementia, elevated PGRS was associated with worse memory (p = 0.

SUBMITTER: Mormino EC 

PROVIDER: S-EPMC4970660 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature