Relation of genomic variants for Alzheimer disease dementia to common neuropathologies.

ABSTRACT:

Objective

To investigate the associations of previously reported Alzheimer disease (AD) dementia genomic variants with common neuropathologies.

Methods

This is a postmortem study including 1,017 autopsied participants from 2 clinicopathologic cohorts. Analyses focused on 22 genomic variants associated with AD dementia in large-scale case-control genome-wide association study (GWAS) meta-analyses. The neuropathologic traits of interest were a pathologic diagnosis of AD according to NIA-Reagan criteria, macroscopic and microscopic infarcts, Lewy bodies (LB), and hippocampal sclerosis. For each variant, multiple logistic regression was used to investigate its association with neuropathologic traits, adjusting for age, sex, and subpopulation structure. We also conducted power an

SUBMITTER: Farfel JM 

PROVIDER: S-EPMC4970661 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature