The ARIC-PET amyloid imaging study: Brain amyloid differences by age, race, sex, and APOE.

ABSTRACT:

Objective

To evaluate differences in amyloid deposition in a community-based cohort without dementia by age, sex, race, education, and APOE ε4 allele status.

Methods

Recruited from the longitudinal Atherosclerosis Risk in Communities study, 329 participants without dementia, ages 67-88 years, were imaged using florbetapir PET at 3 US community sites (Washington County, Maryland; Forsyth County, North Carolina; and Jackson, Mississippi). Standardized uptake value ratios (SUVRs) were calculated; global cortical SUVR >1.2 was evaluated as the primary outcome. Age, race, sex, education level, and number of APOE ε4 alleles were evaluated in multivariable models including vascular risk factors, brain white matter hyperintensity and total intracranial volume, and cognitive status.<

SUBMITTER: Gottesman RF 

PROVIDER: S-EPMC4970663 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature