Chronic migraine headache prevention with noninvasive vagus nerve stimulation: The EVENT study.

ABSTRACT:

Objective

To evaluate the feasibility, safety, and tolerability of noninvasive vagus nerve stimulation (nVNS) for the prevention of chronic migraine (CM) attacks.

Methods

In this first prospective, multicenter, double-blind, sham-controlled pilot study of nVNS in CM prophylaxis, adults with CM (≥15 headache d/mo) entered the baseline phase (1 month) and were subsequently randomized to nVNS or sham treatment (2 months) before receiving open-label nVNS treatment (6 months). The primary endpoints were safety and tolerability. Efficacy endpoints in the intent-to-treat population included change in the number of headache days per 28 days and acute medication use.

Results

Fifty-nine participants (mean age, 39.2 years; mean headache frequency, 21.5 d/mo) were enrolled. Durin

SUBMITTER: Silberstein SD 

PROVIDER: S-EPMC4970666 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature