Estimating time to the most recent common ancestor (TMRCA): comparison and application of eight methods.

ABSTRACT: Investigating how an ancestral population diverges to give rise to distinct subpopulations remains a fundamental pursuit in population genetics. There is broad consensus for the 'Out-of-Africa' hypothesis that states that modern humans arose ∼200 000 years ago in Africa and spread throughout the continent ∼100 000 years ago. This was followed by several waves of major population dispersals across the globe, although the exact nature of the population divergence remains debatable. Existing methods to estimate population divergence time differ in their methodological frameworks and demographic assumptions, and require different types of genetic data as input. These fundamental differences often result in the methods producing inconsistent estimates of the population divergence time, further

SUBMITTER: Zhou J 

PROVIDER: S-EPMC4970674 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature