How Quorum Sensing Connects Sporulation to Necrotrophism in Bacillus thuringiensis.

ABSTRACT: Bacteria use quorum sensing to coordinate adaptation properties, cell fate or commitment to sporulation. The infectious cycle of Bacillus thuringiensis in the insect host is a powerful model to investigate the role of quorum sensing in natural conditions. It is tuned by communication systems regulators belonging to the RNPP family and directly regulated by re-internalized signaling peptides. One such RNPP regulator, NprR, acts in the presence of its cognate signaling peptide NprX as a transcription factor, regulating a set of genes involved in the survival of these bacteria in the insect cadaver. Here, we demonstrate that, in the absence of NprX and independently of its transcriptional activator function, NprR negatively controls sporulation. NprR inhibits expression of Spo0A-regulated gen

SUBMITTER: Perchat S 

PROVIDER: S-EPMC4970707 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature