Oxidized Lipoprotein as a Major Vessel Cell Proliferator in Oxidized Human Serum.

ABSTRACT: Oxidative stress is correlated with the incidence of several diseases such as atherosclerosis and cancer, and oxidized biomolecules have been determined as biomarkers of oxidative stress; however, the detailed molecular relationship between generated oxidation products and the promotion of diseases has not been fully elucidated. In the present study, to clarify the role of serum oxidation products in vessel cell proliferation, which is related to the incidence of atherosclerosis and cancer, the major vessel cell proliferator in oxidized human serum was investigated. Oxidized human serum was prepared by free radical exposure, separated using gel chromatography, and then each fraction was added to several kinds of vessel cells including endothelial cells and smooth muscle cells. It was found

SUBMITTER: Saito Y 

PROVIDER: S-EPMC4970716 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature