Diffuse optical spectroscopic imaging of subcutaneous adipose tissue metabolic changes during weight loss.

ABSTRACT:

Background

Changes in subcutaneous adipose tissue (AT) structure and metabolism have been shown to correlate with the development of obesity and related metabolic disorders. Measurements of AT physiology could provide new insight into metabolic disease progression and response to therapy. An emerging functional imaging technology, diffuse optical spectroscopic imaging (DOSI), was used to obtain quantitative measures of near infrared (NIR) AT optical and physiological properties.

Methods

Ten overweight or obese adults were assessed during 3 months on calorie-restricted diets. DOSI-derived tissue concentrations of hemoglobin, water and lipid and the wavelength-dependent scattering amplitude (A) and slope (b) obtained from 30 abdominal locations and three time points (T0, T6, T

SUBMITTER: Ganesan G 

PROVIDER: S-EPMC4970874 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature