Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression.

ABSTRACT:

Purpose

Castration therapy in advanced prostate cancer eventually fails and leads to the development of castration-resistant prostate cancer (CRPC), which has no cure. Characteristic features of CRPC can be increased androgen receptor (AR) expression and altered transcriptional output. We investigated the expression of nuclear receptor corepressor 1 (NCOR1) in human prostate and prostate cancer and the role of NCOR1 in response to antiandrogens.

Experimental design

NCOR1 protein levels were compared between matched normal prostate and prostate cancer in 409 patient samples. NCOR1 knockdown was used to investigate its effect on bicalutamide response in androgen-dependent prostate cancer cell lines and transcriptional changes associated with the loss of NCOR1. NCOR1 transcript

SUBMITTER: Lopez SM 

PROVIDER: S-EPMC4970919 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature