Kisspeptin Responsiveness Signals Emergence of Reproductive Endocrine Activity: Implications for Human Puberty.

ABSTRACT:

Context

Some patients with idiopathic hypogonadotropic hypogonadism (IHH) undergo spontaneous activation of their hypothalamic-pituitary-gonadal axis resulting in normalization of steroidogenesis and/or gametogenesis, a phenomenon termed reversal.

Objective

To assess the responsiveness of the GnRH neuronal network to exogenous kisspeptin administration in IHH patients who have undergone reversal.

Participants

Six men with congenital IHH and evidence for reversal.

Intervention

Subjects underwent q10 min blood sampling to measure GnRH-induced LH secretion at baseline and in response to iv boluses of kisspeptin (0.24-2.4 nmol/kg) and GnRH (75 ng/kg).

Results

Individuals with sustained reversal of their hypogonadotropism (spontaneous LH pulses) responded to

SUBMITTER: Lippincott MF 

PROVIDER: S-EPMC4971332 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature