Weight Loss and Lowering Androgens Predict Improvements in Health-Related Quality of Life in Women With PCOS.

ABSTRACT:

Context

Polycystic ovary syndrome (PCOS) is associated with reduced health-related quality of life (HRQOL) and increased prevalence of depressive and anxiety disorders. The impact of PCOS-specific treatments on these co-morbidities is unclear.

Objective

To assess the impact of weight loss and decreasing hyperandrogenism on HRQOL and mood and anxiety disorders in women with PCOS.

Design/setting/participants

A secondary analysis of a randomized controlled trial (OWL-PCOS) of preconception treatment conducted at two academic centers in women (age, 18-40 years; body mass index, 27-42 kg/m(2)) with PCOS defined by Rotterdam criteria.

Intervention

Continuous oral contraceptive pill (OCP) or intensive lifestyle intervention or the combination (Combined) for 16 weeks.<

SUBMITTER: Dokras A 

PROVIDER: S-EPMC4971336 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature