Post hoc analysis of the glutamics-trial: intravenous glutamate infusion and use of inotropic drugs after cabg.

ABSTRACT:

Background

Intravenous glutamate reduced the risk of developing severe circulatory failure after isolated coronary artery bypass graft surgery (CABG) for acute coronary syndrome (ACS) in a double-blind randomised clinical trial (GLUTAMICS-ClinicalTrials.gov Identifier: NCT00489827 ). Here our aim was to study if glutamate was associated with reduced the use of inotropes.

Methods

Post-hoc analysis of 824 patients undergoing isolated CABG for ACS in the GLUTAMICS-trial. ICU-records were retrospectively scrutinised including hourly registration of inotropic drug infusion, dosage and total duration during the operation and postoperatively.

Results

ICU-records were found for 171 out of 177 patients who received inotropes perioperatively. Only one fourth of the patients tre

SUBMITTER: Vidlund M 

PROVIDER: S-EPMC4971701 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature