Synaptic plasticity and spatial working memory are impaired in the CD mouse model of Williams-Beuren syndrome.

ABSTRACT: Mice heterozygous for a complete deletion (CD) equivalent to the most common deletion found in individuals with Williams-Beuren syndrome (WBS) recapitulate relevant features of the neurocognitive phenotype, such as hypersociability, along with some neuroanatomical alterations in specific brain areas. However, the pathophysiological mechanisms underlying these phenotypes still remain largely unknown. We have studied the synaptic function and cognition in CD mice using hippocampal slices and a behavioral test sensitive to hippocampal function. We have found that long-term potentiation (LTP) elicited by theta burst stimulation (TBS) was significantly impaired in hippocampal field CA1 of CD animals. This deficit might be associated with the observed alterations in spatial working memory. Howev

SUBMITTER: Borralleras C 

PROVIDER: S-EPMC4971717 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature