Ventricular tachyarrhythmia and sudden cardiac death with domperidone use in Parkinson's disease.

ABSTRACT:

Aim

Domperidone is preferentially used over other antiemetic agents to treat digestive symptoms in Parkinson's disease (PD). Concerns have been raised regarding an increased risk of ventricular tachyarrhythmia and sudden cardiac death (VT/SCD) associated with domperidone in the general population. However, the risk in PD is unknown.

Methods

We conducted a multicentre retrospective cohort study using administrative databases from seven Canadian provinces and the UK Clinical Practice Research Datalink. Using a nested case-control analysis, we estimated the rate ratios (RRs) of VT/SCD associated with domperidone use compared to no use in patients newly-diagnosed with PD. VT/SCD events were identified using administrative medical records and vital statistics with a manual review

SUBMITTER: Renoux C 

PROVIDER: S-EPMC4972162 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature