Evaluation of the risk of cardiovascular events with clarithromycin using both propensity score and self-controlled study designs.

ABSTRACT:

Aim

Some previous studies suggest a long term association between clarithromycin use and cardiovascular events. This study investigates this association for clarithromycin given as part of Helicobacter pylori treatment (HPT).

Methods

Our source population was the Clinical Practice Research Datalink (CPRD), a UK primary care database. We conducted a self-controlled case series (SCCS), a case-time-control study (CTC) and a propensity score adjusted cohort study comparing the rate of cardiovascular events in the 3 years after exposure to HPT containing clarithromycin with exposure to clarithromycin free HPT. Outcomes were first incident diagnosis of myocardial infarction (MI), arrhythmia and stroke. For the cohort analysis we included secondary outcomes all cause and cardiovasc

SUBMITTER: Root AA 

PROVIDER: S-EPMC4972168 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature