Peripheral vasoconstriction induced by β-adrenoceptor blockers: a systematic review and a network meta-analysis.

ABSTRACT:

Aim

Peripheral vasoconstriction has long been described as a vascular adverse effect of β-adrenoceptor blockers. Whether β-adrenoceptor blockers should be avoided in patients with peripheral vascular disease depends on pharmacological properties (e.g. preferential binding to β1 -adrenoreceptors or intrinsic sympathomimetic activity). However, this has not been confirmed in experimental studies. We performed a network meta-analysis in order to assess the comparative risk of peripheral vasoconstriction of different β-adrenoceptor blockers.

Method

We searched for randomized controlled trials (RCTs) including β-adrenoceptor blockers that were published in core clinical journals in the Pubmed database. All RCTs reporting peripheral vasoconstriction as an adverse effect of β-adren

SUBMITTER: Khouri C 

PROVIDER: S-EPMC4972171 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature