Increased Echogenicity and Radiodense Foci on Echocardiogram and MicroCT in Murine Myocarditis.

ABSTRACT:

Objectives

To address the question as to whether echocardiographic and/or microcomputed tomography (microCT) analysis can be utilized to assess the extent of Coxsackie B virus (CVB) induced myocarditis in the absence of left ventricular dysfunction in the mouse.

Background

Viral myocarditis is a significant clinical problem with associated inflammation of the myocardium and myocardial injury. Murine models of myocarditis are commonly used to study the pathophysiology of the disease, but methods for imaging the mouse myocardium have been limited to echocardiographic assessment of ventricular dysfunction and, to a lesser extent, MRI imaging.

Methods

Using a murine model of myocarditis, we used both echocardiography and microCT to assess the extent of myocardial involvem

SUBMITTER: Peter AK 

PROVIDER: S-EPMC4972301 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature