Development of Upper Respiratory Tract Microbiota in Infancy is Affected by Mode of Delivery.

ABSTRACT: Birth by Caesarian section is associated with short- and long-term respiratory morbidity. We hypothesized that mode of delivery affects the development of the respiratory microbiota, thereby altering its capacity to provide colonization resistance and consecutive pathobiont overgrowth and infections. Therefore, we longitudinally studied the impact of mode of delivery on the nasopharyngeal microbiota development from birth until six months of age in a healthy, unselected birth cohort of 102 children (n=761 samples). Here, we show that the respiratory microbiota develops within one day from a variable mixed bacterial community towards a Streptococcus viridans-predominated profile, regardless of mode of delivery. Within the first week, rapid niche differentiation had occurred; initially with

SUBMITTER: Bosch AATM 

PROVIDER: S-EPMC4972531 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature