Donor-specific antibodies require preactivated immune system to harm renal transplant.

ABSTRACT:

Background

It is an unresolved issue why some kidney transplant recipients with pretransplant donor-specific HLA antibodies (DSA) show a high transplant failure rate, whereas in other patients DSA do not harm the graft. We investigated whether help from preactivated T-cells might be necessary for DSA to exert a deleterious effect.

Methods

The impact of pretransplant DSA and immune activation marker soluble CD30 (sCD30) on 3-year graft survival was analyzed in 385 presensitized kidney transplant recipients.

Findings

A deleterious influence of pretransplant DSA on graft survival was evident only in patients who were positive for the immune activation marker sCD30. In the absence of sCD30 positivity, 3-year graft survival was virtually identical in patients with or witho

SUBMITTER: Susal C 

PROVIDER: S-EPMC4972543 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature