Tuning Reaction and Diffusion Mediated Degradation of Enzyme-Sensitive Hydrogels.

ABSTRACT: Enzyme-sensitive hydrogels are promising for cell encapsulation and tissue engineering, but result in complex spatiotemporal degradation behavior that is characteristic of reaction-diffusion mechanisms. An experimental and theoretical approach is presented to identify dimensionless quantities that serve as a design tool for engineering enzyme-sensitive hydrogels with controlled degradation patterns by tuning the initial hydrogel properties and enzyme kinetics.

SUBMITTER: Skaalure SC 

PROVIDER: S-EPMC4972608 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature