Association of Marijuana Use With Blunted Nucleus Accumbens Response to Reward Anticipation.

ABSTRACT:

Importance

Marijuana use may alter ventral striatal response to reward, which might heighten susceptibility to substance use disorder. Longitudinal research is needed to determine the effects of marijuana use on neural function involved in reward response.

Objective

To determine whether marijuana use among young adults prospectively affects nucleus accumbens (NAcc) activation during reward anticipation.

Design, setting, and participants

One hundred eight young adults were recruited from the Michigan Longitudinal Study, an ongoing study of youth at high risk for substance use disorder and a contrast sample of control families. Participants underwent 3 consecutive functional magnetic resonance imaging scans at approximate ages of 20 (time 1), 22 (time 2), and 24 (time 3

SUBMITTER: Martz ME 

PROVIDER: S-EPMC4972653 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature