Etravirine Pharmacokinetics in HIV-Infected Pregnant Women.

ABSTRACT:

Background

The study goal was to describe etravirine pharmacokinetics during pregnancy and postpartum in HIV-infected women.

Methods

IMPAACT P1026s and PANNA are on-going, non-randomized, open-label, parallel-group, multi-center phase-IV prospective studies in HIV-infected pregnant women. Intensive steady-state 12-h pharmacokinetic profiles were performed from 2nd trimester through postpartum. Etravirine was measured at two labs using validated ultra performance liquid chromatography (detection limits: 0.020 and 0.026 mcg/mL).

Results

Fifteen women took etravirine 200 mg twice-daily. Etravirine AUC0-12 was higher in the 3rd trimester compared to paired postpartum data by 34% (median 8.3 vs. 5.3 mcg*h/mL, p = 0.068). Etravirine apparent oral clearance was significantly

SUBMITTER: Mulligan N 

PROVIDER: S-EPMC4972814 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature