Inter-observer and inter-examination variability of manual vertebral bone attenuation measurements on computed tomography.

ABSTRACT:

Objective

To determine inter-observer and inter-examination variability of manual attenuation measurements of the vertebrae in low-dose unenhanced chest computed tomography (CT).

Methods

Three hundred and sixty-seven lung cancer screening trial participants who underwent baseline and repeat unenhanced low-dose CT after 3 months because of an indeterminate lung nodule were included. The CT attenuation value of the first lumbar vertebrae (L1) was measured in all CTs by one observer to obtain inter-examination reliability. Six observers performed measurements in 100 randomly selected CTs to determine agreement with limits of agreement and Bland-Altman plots and reliability with intraclass correlation coefficients (ICCs). Reclassification analyses were performed using a threshol

SUBMITTER: Pompe E 

PROVIDER: S-EPMC4972882 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature