TLR9 re-expression in cancer cells extends the S-phase and stabilizes p16(INK4a) protein expression.

ABSTRACT: Toll-like receptor 9 (TLR9) recognizes bacterial, viral or cell damage-associated DNA, which initiates innate immune responses. We have previously shown that TLR9 expression is downregulated in several viral induced cancers including HPV16-induced cervical neoplasia. Findings supported that downregulation of TLR9 expression is involved in loss of anti-viral innate immunity allowing an efficient viral replication. Here we investigated the role of TLR9 in altering the growth of transformed epithelial cells. Re-introducing TLR9 under the control of an exogenous promoter in cervical or head and neck cancer patient-derived cells reduced cell proliferation, colony formation and prevented independent growth of cells under soft agar. Neither TLR3, 7, nor the TLR adapter protein MyD88 expression ha

SUBMITTER: Parroche P 

PROVIDER: S-EPMC4972902 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature