Optimizing lung aeration at birth using a sustained inflation and positive pressure ventilation in preterm rabbits.

ABSTRACT:

Background

A sustained inflation (SI) facilitates lung aeration, but the most effective pressure and duration are unknown. We investigated the effect of gestational age (GA) and airway liquid volume on the required inflation pressure and SI duration.

Methods

Rabbit kittens were delivered at 27, 29, and 30 d gestation, intubated and airway liquid was aspirated. Either no liquid (control) or 30 ml/kg of liquid was returned to the airways. Lung gas volumes were measured by plethysmography and phase-contrast X-ray-imaging. Starting at 22 cmH2O, airway pressure was increased until airflow commenced and pressure was then held constant. The SI was truncated when 20 ml/kg air had entered the lung and ventilation continued with intermittent positive pressure ventilation (iPPV).

Re

SUBMITTER: Te Pas AB 

PROVIDER: S-EPMC4973011 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature