Anti-cholinesterases and memory improving effects of Vietnamese Xylia xylocarpa.

ABSTRACT:

Background

Alzheimer's disease (AD) is the most common cause of dementia among the elderly and is characterized by loss of memory and other cognitive functions. An increase in AChE (a key enzyme in the cholinergic nervous system) levels around β-amyloid plaques and neurofibrillary tangles is a common feature of AD neuropathology. Amnesic effects of scopolamine (acetylcholine receptor antagonist) can be investigated in various behavioral tests such as Morris water maze, object recognition, Y-maze, and passive avoidance. In the scope of this paper, we report the anti-AChE, anti-BChE properties of the isolated compound and the in vivo effects of the methanolic extract of Xylia xylocarpa (MEXX) on scopolamine-induced memory deficit.

Results

In further phytochemistry study, a new

SUBMITTER: Lam LM 

PROVIDER: S-EPMC4973094 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature