Prognostic nomogram and score to predict overall survival in locally advanced untreated pancreatic cancer (PROLAP).

ABSTRACT:

Background

The management of locally advanced pancreatic cancer (LAPC) patients remains controversial. Better discrimination for overall survival (OS) at diagnosis is needed. We address this issue by developing and validating a prognostic nomogram and a score for OS in LAPC (PROLAP).

Methods

Analyses were derived from 442 LAPC patients enrolled in the LAP07 trial. The prognostic ability of 30 baseline parameters was evaluated using univariate and multivariate Cox regression analyses. Performance assessment and internal validation of the final model were done with Harrell's C-index, calibration plot and bootstrap sample procedures. On the basis of the final model, a prognostic nomogram and a score were developed, and externally validated in 106 consecutive LAPC patients treat

SUBMITTER: Vernerey D 

PROVIDER: S-EPMC4973163 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature