Childhood body mass index and height and risk of histologic subtypes of endometrial cancer.

ABSTRACT:

Background

Endometrial cancer risk factors include adult obesity and taller stature, but the influence of size earlier in life is incompletely understood. We examined whether childhood body mass index (BMI; kg m(-2)) and height were associated with histologic subtypes of endometrial cancer.

Methods

From the Copenhagen School Health Records Register, 155 505 girls born 1930-1989 with measured weights and heights from 7 to 13 years were linked to health registers. BMI and height were transformed to age-specific z-scores. Hazard ratios (HRs) and 95% confidence intervals were estimated by Cox regressions.

Results

A total of 1020 endometrial cancers were recorded. BMI was non-linearly associated with all endometrial cancers, oestrogen-dependent cancers and the subtype of e

SUBMITTER: Aarestrup J 

PROVIDER: S-EPMC4973214 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature