Loss of anti-contractile effect of perivascular adipose tissue in offspring of obese rats.

ABSTRACT:

Rationale

Maternal obesity pre-programmes offspring to develop obesity and associated cardiovascular disease. Perivascular adipose tissue (PVAT) exerts an anti-contractile effect on the vasculature, which is reduced in hypertension and obesity.

Objective

The objective of this study was to determine whether maternal obesity pre-programmes offspring to develop PVAT dysfunction in later life.

Methods

Female Sprague-Dawley rats were fed a diet containing 10% (control) or 45% fat (high fat diet, HFD) for 12 weeks prior to mating and during pregnancy and lactation. Male offspring were killed at 12 or 24 weeks of age and tension in PVAT-intact or -denuded mesenteric artery segments was measured isometrically. Concentration-response curves were constructed to U46619 and norep

SUBMITTER: Zaborska KE 

PROVIDER: S-EPMC4973217 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature