Ontology highlight
ABSTRACT:
SUBMITTER: Fagegaltier D
PROVIDER: S-EPMC4973292 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Genes & development 20160701 14
Germline genes often become re-expressed in soma-derived human cancers as "cancer/testis antigens" (CTAs), and piRNA (PIWI-interacting RNA) pathway proteins are found among CTAs. However, whether and how the piRNA pathway contributes to oncogenesis in human neoplasms remain poorly understood. We found that oncogenic Ras combined with loss of the Hippo tumor suppressor pathway reactivates a primary piRNA pathway in Drosophila somatic cells coincident with oncogenic transformation. In these cells, ...[more]