MiR-30c regulates proliferation, apoptosis and differentiation via the Shh signaling pathway in P19 cells.

ABSTRACT: MicroRNAs (miRNAs) are small, non-coding single-stranded RNAs that suppress protein expression by binding to the 3' untranslated regions of their target genes. Many studies have shown that miRNAs have important roles in congenital heart diseases (CHDs) by regulating gene expression and signaling pathways. We previously found that miR-30c was highly expressed in the heart tissues of aborted embryos with ventricular septal defects. Therefore, this study aimed to explore the effects of miR-30c in CHDs. miR-30c was overexpressed or knocked down in P19 cells, a myocardial cell model that is widely used to study cardiogenesis. We found that miR-30c overexpression not only increased cell proliferation by promoting cell entry into S phase but also suppressed cell apoptosis. In addition, we found t

SUBMITTER: Liu X 

PROVIDER: S-EPMC4973315 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature