Tumorigenic potential is restored during differentiation in fusion-reprogrammed cancer cells.

ABSTRACT: Detailed understanding of the mechanistic steps underlying tumor initiation and malignant progression is critical for insights of potentially novel therapeutic modalities. Cellular reprogramming is an approach of particular interest because it can provide a means to reset the differentiation state of the cancer cells and to revert these cells to a state of non-malignancy. Here, we investigated the relationship between cellular differentiation and malignant progression by the fusion of four independent mouse cancer cell lines from different tissues, each with differing developmental potentials, to pluripotent mouse embryonic stem (ES) cells. Fusion was accompanied by loss of differentiated properties of the four parental cancer cell lines and concomitant emergence of pluripotency, demonstra

SUBMITTER: Yao J 

PROVIDER: S-EPMC4973342 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature