The multiple evolutionary origins of the eukaryotic N-glycosylation pathway.

ABSTRACT:

Background

The N-glycosylation is an essential protein modification taking place in the membranes of the endoplasmic reticulum (ER) in eukaryotes and the plasma membranes in archaea. It shares mechanistic similarities based on the use of polyisoprenol lipid carriers with other glycosylation pathways involved in the synthesis of bacterial cell wall components (e.g. peptidoglycan and teichoic acids). Here, a phylogenomic analysis was carried out to examine the validity of rival hypotheses suggesting alternative archaeal or bacterial origins to the eukaryotic N-glycosylation pathway.

Results

The comparison of several polyisoprenol-based glycosylation pathways from the three domains of life shows that most of the implicated proteins belong to a limited number of superfamilies. T

SUBMITTER: Lombard J 

PROVIDER: S-EPMC4973528 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature