Regulation of proliferation and histone acetylation in embryonic neural precursors by CREB/CREM signaling.

ABSTRACT: The transcription factor CREB (cAMP-response element binding protein) regulates differentiation, migration, survival and activity-dependent gene expression in the developing and mature nervous system. However, its specific role in the proliferation of embryonic neural progenitors is still not completely understood. Here we investigated how CREB regulates proliferation of mouse embryonic neural progenitors by a conditional mutant lacking Creb gene in neural progenitors. In parallel, we explored possible compensatory effects by the genetic ablation of another member of the same gene family, the cAMP-responsive element modulator (Crem). We show that CREB loss differentially impaired the proliferation, clonogenic potential and self-renewal of precursors derived from the ganglionic eminence (GE

SUBMITTER: Parlato R 

PROVIDER: S-EPMC4973597 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature