Targeting aspirin in acute disabling ischemic stroke: an individual patient data meta-analysis of three large randomized trials.

ABSTRACT:

Background

Aspirin is of moderate overall benefit for patients with acute disabling ischemic stroke. It is unclear whether functional outcome could be improved after stroke by targeting aspirin to patients with a high risk of recurrent thrombosis or a low risk of haemorrhage.

Aims

We aimed to determine whether patients at higher risk of thrombotic events or poor functional outcome, or lower risk of major haemorrhage had a greater absolute risk reduction of poor functional outcome with aspirin than the average patient.

Methods

We used data on individual ischemic stroke patients from three large trials of aspirin vs. placebo in acute ischemic stroke: the first International Stroke Trial (n = 18,372), the Chinese Acute Stroke Trial (n = 20,172) and the Multicentre Acute

SUBMITTER: Thompson DD 

PROVIDER: S-EPMC4973666 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature