Bleeding Risk with Long-Term Low-Dose Aspirin: A Systematic Review of Observational Studies.

ABSTRACT:

Background

Low-dose aspirin has proven effectiveness in secondary and primary prevention of cardiovascular events, but is also associated with an increased risk of major bleeding events. For primary prevention, this absolute risk must be carefully weighed against the benefits of aspirin; such assessments are currently limited by a lack of data from general populations.

Methods

Systematic searches of Medline and Embase were conducted to identify observational studies published between 1946 and 4 March 2015 that reported the risks of gastrointestinal (GI) bleeding or intracranial hemorrhage (ICH) with long-term, low-dose aspirin (75-325 mg/day). Pooled estimates of the relative risk (RR) for bleeding events with aspirin versus non-use were calculated using random-effects model

SUBMITTER: Garcia Rodriguez LA 

PROVIDER: S-EPMC4973997 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature