A Proteomic Investigation of Hepatic Resistance to Ascaris in a Murine Model.

ABSTRACT: The helminth Ascaris causes ascariasis in both humans and pigs. Humans, especially children, experience significant morbidity including respiratory complications, growth deficits and intestinal obstruction. Given that 800 million people worldwide are infected by Ascaris, this represents a significant global public health concern. The severity of the symptoms and associated morbidity are related to the parasite burden and not all hosts are infected equally. While the pathology of the disease has been extensively examined, our understanding of the molecular mechanisms underlying resistance and susceptibility to this nematode infection is poor. In order to investigate host differences associated with heavy and light parasite burden, an experimental murine model was developed utilising Ascaris

SUBMITTER: Deslyper G 

PROVIDER: S-EPMC4974003 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature