BCL11A Haploinsufficiency Causes an Intellectual Disability Syndrome and Dysregulates Transcription.

ABSTRACT: Intellectual disability (ID) is a common condition with considerable genetic heterogeneity. Next-generation sequencing of large cohorts has identified an increasing number of genes implicated in ID, but their roles in neurodevelopment remain largely unexplored. Here we report an ID syndrome caused by de novo heterozygous missense, nonsense, and frameshift mutations in BCL11A, encoding a transcription factor that is a putative member of the BAF swi/snf chromatin-remodeling complex. Using a comprehensive integrated approach to ID disease modeling, involving human cellular analyses coupled to mouse behavioral, neuroanatomical, and molecular phenotyping, we provide multiple lines of functional evidence for phenotypic effects. The etiological missense variants cluster in the amino-terminal regi

SUBMITTER: Dias C 

PROVIDER: S-EPMC4974071 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature