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What's better for me? Fundamental role for lateral habenula in promoting subjective decision biases.

ABSTRACT: The lateral habenula (LHb) is believed to convey an aversive or 'anti-reward' signal, but its contribution to reward-related action selection is unknown. We found that LHb inactivation abolished choice biases, making rats indifferent when choosing between rewards associated with different subjective costs and magnitudes, but not larger or smaller rewards of equal cost. Thus, instead of serving as an aversion center, the evolutionarily conserved LHb acts as a preference center that is integral for expressing subjective decision biases.

SUBMITTER: Stopper CM

PROVIDER: S-EPMC4974073 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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What's better for me? Fundamental role for lateral habenula in promoting subjective decision biases.

Stopper Colin M CM Floresco Stan B SB

Nature neuroscience 20131124 1

The lateral habenula (LHb) is believed to convey an aversive or 'anti-reward' signal, but its contribution to reward-related action selection is unknown. We found that LHb inactivation abolished choice biases, making rats indifferent when choosing between rewards associated with different subjective costs and magnitudes, but not larger or smaller rewards of equal cost. Thus, instead of serving as an aversion center, the evolutionarily conserved LHb acts as a preference center that is integral fo ...[more]

PMID: 24270185

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Acute social isolation alters synaptic plasticity in lateral habenula and social decision

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Substantial projections from the lateral division of the lateral habenula to the dorsal raphe nucleus and from the lateral habenula to the contralateral ventral tegmental area.

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