Long-term soy consumption and tumor tissue MicroRNA and gene expression in triple-negative breast cancer.

ABSTRACT:

Background

Soy food intake may have protective effects against the risk for breast cancer, including estrogen receptor (ER)-negative breast cancer. However, the underlying molecular mechanisms remain unclear.

Methods

To evaluate the association of soy intake with the expression of microRNAs (miRNAs) and genes in the tumor tissue of patients with triple-negative breast cancer (TNBC; ie, breast cancer lacking expression of ER, progesterone receptor, and human epidermal growth factor receptor 2), the expression of 800 miRNAs and 302 genes were measured with NanoString nCounter assays in formalin-fixed, paraffin-embedded tumor tissue from 272 TNBC patients. Soy intake during the 1-year period before the cancer diagnosis was assessed with a validated food-frequency questionnaire.

SUBMITTER: Guo X 

PROVIDER: S-EPMC4974138 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature